- Associate Professor of Medicine, Cell Biology and Physiology
- Assistant Vice Chancellor/Dean for Animal Affairs
- Chairman, Animal Studies Committee, Washington University School of Medicine
Thrombosis and neointima formation.
Research in the Abendschein large animal translational physiology laboratory focuses primarily on development of novel antithrombotic approaches for use during acute myocardial infarction and stroke, in which vascular injury is an underlying cause.
Over the last three decades, we have used a variety of experimental animal models systems to study coagulation proteases and inflammatory molecules in vascular remodeling, using large animal models.
The lab has facilitated development of many conjunctive therapeutics for fibrinolysis and angioplasty, including platelet glycoprotein IIb/IIIa inhibitors, hirudin, direct factor Xa inhibitors, and tissue factor pathway inhibitor.
More recent studies have focused on development of novel antithrombotics and nanoparticulate delivery systems that could be used conjointly with or independent of a supporting vascular stent to provide targeted and safe antithrombotic therapy after vascular injury.
The lab is also interested in how the metabolic syndrome and diabetes affect the time course and type of therapeutics required to achieve passivation of the injured arterial wall.
Trainees are responsible for:
- Conducting hands-on experiments in intact animal models of disease and vascular injury
- Developing strategies to image vessels, thrombosis, and associated inhibitors
- Using assays for coagulation protease activities, histopathologic analysis of therapeutic efficacy
- Computing the statistical significance of data
- Composing results of studies for presentation and publication
Phone: 314-362-8925 (Office) | 314-362-8924 (Lab)