The Center for Cardiovascular Research (CCR) at Washington University School of Medicine supports basic research focused on understanding the biologic processes that are responsible for cardiovascular disease.
A major objective of the CCR is to establish novel interfaces among cardiovascular researchers in diverse scientific disciplines, including:
- Developmental Biology
- Molecular and cellular biology
- Physiology and Biophysics
Accordingly, the CCR provides a unique research environment for scientists with distinct backgrounds who have common interests in diseases of the heart and vasculature. In addition, the CCR facilitates interactions between basic scientists and clinicians engaged in patient-oriented research. The CCR also supports a cutting-edge Mouse Cardiovascular Phenotyping Core.
Current research efforts in the CCR include:
- Cellular and molecular basis of heart failure
- Cellular responses to myocardial injury
- Mechanisms of cell death
- Roles of autophagy in atherosclerosis and heart disease
- Genomic predictors of cardiovascular disease risk and complications
- Inflammation in cardiac injury and repair
- Cardiac electrophysiology and arrhythmia mechanisms
- Cardiac remodeling
The CCR supports the basic science research faculty members in the Cardiovascular Division and those with primary appointments in other departments throughout the University.
The Cardiovascular Division at Washington University School of Medicine comprises of 75 faculty members, all renowned for their contributions to the basic, translational and clinical sciences. Outstanding clinical services are provided through the Division’s faculty and highly-competitive cardiovascular disease fellows.
Interdisciplinary research within the CCR is performed in collaboration with investigators from multiple departments and research centers including:
- Cardiac Bioelectricity and Arrhythmia Center (CBAC)
- Cardiovascular Imaging Laboratory
- Center for the Investigation of Membrane Excitability Diseases (CIMED)
- Consortium for Translational Research in Advanced Imaging and Nanomedicine
- Center for Pharmacogenomics
- Center for Cardiovascular Outcomes Research
One of the major goals of the CCR is to provide an exciting and scientifically rigorous training environment for graduate students, PhD, MD, and MD/PhD postdoctoral fellows and MD and MD/PhD cardiology fellows. The diverse strengths of the CCR and its affiliated investigators provide a unique training environment for students and fellows. Predoctoral and Postdoctoral train in the CCR is supported by two NHLBI-sponsored T32 training grants that provide one to two years of research support. Students, fellows, and faculty meet twice weekly in the CCR Trainee and Faculty (internal and visiting professor) seminar series.